Exposure to oestrogen linked to less brain shrinkage in midlife women
Exposure to oestrogen linked to less brain shrinkage in midlife women
Provider: Neurology
Type: Link
Title: Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife
Description: Objective. To examine associations between indicators of estrogen exposure from women’s reproductive history and brain MRI biomarkers of Alzheimer’s disease (AD) in midlife. Methods. We evaluated 99 cognitively normal women ages 52+6 years, and 29 men ages 52+7 years, with reproductive history data, neuropsychological testing, and volumetric MRI scans. We used multiple regressions to examine associations between reproductive history indicators, voxel-wise gray matter volume (GMV), memory and global cognition scores, adjusting for demographics and midlife health indicators. Exposure variables were menopause status, age at menarche, age at menopause, reproductive span, hysterectomy status, number of children and pregnancies, use of menopause hormonal therapy (HT) and hormonal contraceptives (HC). Results. All menopausal groups exhibited lower GMV in AD-vulnerable regions as compared to men, with peri-menopausal and post-menopausal groups also exhibiting lower GMV in temporal cortex as compared to the pre-menopausal group. Reproductive span, number of children and pregnancies, use of HT and HC were positively associated with GMV, chiefly in temporal cortex, frontal cortex, and precuneus, independent of age, APOE-4 status, and midlife health indicators. Although reproductive history indicators were not directly associated with cognitive measures, GMV in temporal regions was positively associated with memory and global cognition scores. Conclusions. Reproductive history events signaling more estrogen exposure, such as pre-menopausal status, longer reproductive span, higher number of children, use of HT and HC, were associated with larger GMV in midlife women. Further studies are needed to elucidate sex-specific biological pathways through which reproductive history influences cognitive aging and AD-risk.
Exposure to oestrogen linked to less brain shrinkage in midlife women
Provider: Alzheimer's Research UK
Type: Link
Title: Genes and dementia - Alzheimer's Research UK
Description: Questions about genes and dementia? Find information on genetic risk and genetic testing for dementia here.
Exposure to oestrogen linked to less brain shrinkage in midlife women
Provider: Alzheimersresearchuk
Type: JPG
Exposure to oestrogen linked to less brain shrinkage in midlife women
Provider: Twitter
Type: Twitter
Exposure to oestrogen linked to less brain shrinkage in midlife women
Provider: Neurology
Type: Link
Title: Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife
Description: Objective. To examine associations between indicators of estrogen exposure from women’s reproductive history and brain MRI biomarkers of Alzheimer’s disease (AD) in midlife. Methods. We evaluated 99 cognitively normal women ages 52+6 years, and 29 men ages 52+7 years, with reproductive history data, neuropsychological testing, and volumetric MRI scans. We used multiple regressions to examine associations between reproductive history indicators, voxel-wise gray matter volume (GMV), memory and global cognition scores, adjusting for demographics and midlife health indicators. Exposure variables were menopause status, age at menarche, age at menopause, reproductive span, hysterectomy status, number of children and pregnancies, use of menopause hormonal therapy (HT) and hormonal contraceptives (HC). Results. All menopausal groups exhibited lower GMV in AD-vulnerable regions as compared to men, with peri-menopausal and post-menopausal groups also exhibiting lower GMV in temporal cortex as compared to the pre-menopausal group. Reproductive span, number of children and pregnancies, use of HT and HC were positively associated with GMV, chiefly in temporal cortex, frontal cortex, and precuneus, independent of age, APOE-4 status, and midlife health indicators. Although reproductive history indicators were not directly associated with cognitive measures, GMV in temporal regions was positively associated with memory and global cognition scores. Conclusions. Reproductive history events signaling more estrogen exposure, such as pre-menopausal status, longer reproductive span, higher number of children, use of HT and HC, were associated with larger GMV in midlife women. Further studies are needed to elucidate sex-specific biological pathways through which reproductive history influences cognitive aging and AD-risk.
Exposure to oestrogen linked to less brain shrinkage in midlife women
Provider: Alzheimer's Research UK
Type: Link
Title: Exposure to oestrogen linked to less brain shrinkage in midlife women - Alzheimer's Research UK
Description: Researchers have found a link between indicators of longer oestrogen exposure and reduced brain shrinkage in midlife women.
Exposure to oestrogen linked to less brain shrinkage in midlife women
Provider: Alzheimer's Research UK
Type: Link
Title: Alzheimer's Research UK - the UK's leading Alzheimer's research charity
Description: Alzheimer's Research UK are the UK's leading Alzheimer's research charity aiming to find a cure for dementia. Together we have the power to make breakthroughs possible.
Exposure to oestrogen linked to less brain shrinkage in midlife women
Provider: View Original
Type: Link
Title: Exposure to oestrogen linked to less brain shrinkage in midlife women - Alzheimer's Research UK
Description: Researchers have found a link between indicators of longer oestrogen exposure and reduced brain shrinkage in midlife women.
Oarsome duo nominated for ‘Fundraiser of the Year’ at ITV’s Pride of Britain Awards
Oarsome duo nominated for ‘Fundraiser of the Year’ at ITV’s Pride of Britain Awards
Provider: Alzheimersresearchuk
Type: JPG
Oarsome duo nominated for ‘Fundraiser of the Year’ at ITV’s Pride of Britain Awards
Provider: Alzheimersresearchuk
Type: JPG
Oarsome duo nominated for ‘Fundraiser of the Year’ at ITV’s Pride of Britain Awards
Provider: Alzheimersresearchuk
Type: JPG
Oarsome duo nominated for ‘Fundraiser of the Year’ at ITV’s Pride of Britain Awards
Provider: Twitter
Type: Twitter
Oarsome duo nominated for ‘Fundraiser of the Year’ at ITV’s Pride of Britain Awards
Provider: JustGiving
Type: Link
Title: Frank Rothwell's Talisker Whisky Atlantic Challenge 2020
Description: Help Frank Rothwell raise money to support Alzheimer's Research UK
Oarsome duo nominated for ‘Fundraiser of the Year’ at ITV’s Pride of Britain Awards
Provider: Alzheimer's Research UK
Type: Link
Title: Oarsome duo nominated for ‘Fundraiser of the Year’ at ITV’s Pride of Britain Awards - Alzheimer's Research UK
Description: Following their incredible rowing challenges, 71 year old Frank Rothwell and 81 year old Major Mick Stanley joined some of the nation’s unsung heroes for the prestigious award
Oarsome duo nominated for ‘Fundraiser of the Year’ at ITV’s Pride of Britain Awards
Provider: Alzheimer's Research UK
Type: Link
Title: Alzheimer's Research UK - the UK's leading Alzheimer's research charity
Description: Alzheimer's Research UK are the UK's leading Alzheimer's research charity aiming to find a cure for dementia. Together we have the power to make breakthroughs possible.
Oarsome duo nominated for ‘Fundraiser of the Year’ at ITV’s Pride of Britain Awards
Provider: View Original
Type: Link
Title: Oarsome duo nominated for ‘Fundraiser of the Year’ at ITV’s Pride of Britain Awards - Alzheimer's Research UK
Description: Following their incredible rowing challenges, 71 year old Frank Rothwell and 81 year old Major Mick Stanley joined some of the nation’s unsung heroes for the prestigious award
Research volunteers help detect poorer memory in those who were more anxious during pandemic
Research volunteers help detect poorer memory in those who were more anxious during pandemic
Provider: Protectstudy
Type: Link
Title: Home Page - PROTECT
Research volunteers help detect poorer memory in those who were more anxious during pandemic
Provider: Alzheimersresearchuk
Type: JPG
Research volunteers help detect poorer memory in those who were more anxious during pandemic
Provider: Alzheimer's Research UK
Type: Link
Title: Volunteering for Alzheimer's Research UK - Alzheimer's Research UK
Description: Volunteers are a vital force in our efforts to make life-changing breakthroughs possible. Get involved and help us make a major impact.
Research volunteers help detect poorer memory in those who were more anxious during pandemic
Provider: Twitter
Type: Twitter
Research volunteers help detect poorer memory in those who were more anxious during pandemic
Provider: Alzheimer's Research UK
Type: Link
Title: Research volunteers help detect poorer memory in those who were more anxious during pandemic - Alzheimer's Research UK
Description: New research suggests older people who were more anxious and depressed during the first year of the COVID-19 pandemic had an average decline in their short-term memory equivalent to six years of natural ageing.
Research volunteers help detect poorer memory in those who were more anxious during pandemic
Provider: Alzheimer's Research UK
Type: Link
Title: Alzheimer's Research UK - the UK's leading Alzheimer's research charity
Description: Alzheimer's Research UK are the UK's leading Alzheimer's research charity aiming to find a cure for dementia. Together we have the power to make breakthroughs possible.
Research volunteers help detect poorer memory in those who were more anxious during pandemic
Provider: View Original
Type: Link
Title: Research volunteers help detect poorer memory in those who were more anxious during pandemic - Alzheimer's Research UK
Description: New research suggests older people who were more anxious and depressed during the first year of the COVID-19 pandemic had an average decline in their short-term memory equivalent to six years of natural ageing.
Diet high in inflammation linked with increased risk of dementia, study suggests
Diet high in inflammation linked with increased risk of dementia, study suggests
Provider: Neurology
Type: Link
Title: Diet Inflammatory Index and Dementia Incidence: A Population-Based Study
Description: Background and objectives: Aging is characterized by a functional shift of the immune system towards a proinflammatory phenotype. This derangement has been associated with cognitive decline and has been implicated in the pathogenesis of dementia. Diet can modulate systemic inflammation; thus, it may be a valuable tool to counteract the associated risks for cognitive impairment and dementia. The present study aimed to explore the associations between the inflammatory potential of diet, assessed using an easily applicable, population-based, biomarker-validated diet inflammatory index (DII), and the risk for dementia in community-dwelling older adults. Methods: Individuals from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD) were included in the present cohort study. Participants were recruited through random population sampling, and were followed for a mean of 3.05 (SD=0.85) years. Dementia diagnosis was based on standard clinical criteria. Those with baseline dementia and/or missing cognitive follow-up data were excluded from the analyses. The inflammatory potential of diet was assessed through a DII score which considers literature-derived associations of 45 food parameters with levels of pro- and anti-inflammatory cytokines in the blood; higher values indicated a more pro-inflammatory diet. Consumption frequencies were derived from a detailed food frequency questionnaire, and were standardized to representative dietary intake normative data from 11 different countries. Analysis of dementia incidence as a function of baseline DII scores was performed by Cox proportional hazards models. Results: Analyses included 1059 individuals (mean age=73.1 years; 40.3% males; mean education=8.2 years), 62 of whom developed incident dementia. Each additional unit of DII was associated with a 21% increase in the risk for dementia incidence [HR=1.21 (1.03 – 1.42); p=0.023]. Compared to participants in the lowest DII tertile, participants in the highest one (maximal pro-inflammatory diet potential) were 3 [(1.2 – 7.3); p=0.014] times more likely to develop incident dementia. The test for trend was also significant, indicating a potential dose-response relationship (p=0.014). Conclusions: In the present study, higher DII scores (indicating greater pro-inflammatory diet potential) were associated with an increased risk for incident dementia. These findings might avail the development of primary dementia preventive strategies through tailored and precise dietary interventions.
Diet high in inflammation linked with increased risk of dementia, study suggests
Provider: Twitter
Type: Twitter
Diet high in inflammation linked with increased risk of dementia, study suggests
Provider: Neurology
Type: Link
Title: Diet Inflammatory Index and Dementia Incidence: A Population-Based Study
Description: Background and objectives: Aging is characterized by a functional shift of the immune system towards a proinflammatory phenotype. This derangement has been associated with cognitive decline and has been implicated in the pathogenesis of dementia. Diet can modulate systemic inflammation; thus, it may be a valuable tool to counteract the associated risks for cognitive impairment and dementia. The present study aimed to explore the associations between the inflammatory potential of diet, assessed using an easily applicable, population-based, biomarker-validated diet inflammatory index (DII), and the risk for dementia in community-dwelling older adults. Methods: Individuals from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD) were included in the present cohort study. Participants were recruited through random population sampling, and were followed for a mean of 3.05 (SD=0.85) years. Dementia diagnosis was based on standard clinical criteria. Those with baseline dementia and/or missing cognitive follow-up data were excluded from the analyses. The inflammatory potential of diet was assessed through a DII score which considers literature-derived associations of 45 food parameters with levels of pro- and anti-inflammatory cytokines in the blood; higher values indicated a more pro-inflammatory diet. Consumption frequencies were derived from a detailed food frequency questionnaire, and were standardized to representative dietary intake normative data from 11 different countries. Analysis of dementia incidence as a function of baseline DII scores was performed by Cox proportional hazards models. Results: Analyses included 1059 individuals (mean age=73.1 years; 40.3% males; mean education=8.2 years), 62 of whom developed incident dementia. Each additional unit of DII was associated with a 21% increase in the risk for dementia incidence [HR=1.21 (1.03 – 1.42); p=0.023]. Compared to participants in the lowest DII tertile, participants in the highest one (maximal pro-inflammatory diet potential) were 3 [(1.2 – 7.3); p=0.014] times more likely to develop incident dementia. The test for trend was also significant, indicating a potential dose-response relationship (p=0.014). Conclusions: In the present study, higher DII scores (indicating greater pro-inflammatory diet potential) were associated with an increased risk for incident dementia. These findings might avail the development of primary dementia preventive strategies through tailored and precise dietary interventions.
Diet high in inflammation linked with increased risk of dementia, study suggests
Provider: Alzheimer's Research UK
Type: Link
Title: Diet high in inflammation linked with increased risk of dementia, study suggests - Alzheimer's Research UK
Description: Researchers have linked a high inflammatory diet - food associated with markers of inflammation - with an increased risk of dementia.
Diet high in inflammation linked with increased risk of dementia, study suggests
Provider: Alzheimer's Research UK
Type: Link
Title: Alzheimer's Research UK - the UK's leading Alzheimer's research charity
Description: Alzheimer's Research UK are the UK's leading Alzheimer's research charity aiming to find a cure for dementia. Together we have the power to make breakthroughs possible.
Diet high in inflammation linked with increased risk of dementia, study suggests
Provider: View Original
Type: Link
Title: Diet high in inflammation linked with increased risk of dementia, study suggests - Alzheimer's Research UK
Description: Researchers have linked a high inflammatory diet - food associated with markers of inflammation - with an increased risk of dementia.
Potential vaccine against Alzheimer’s show promise in mice
Potential vaccine against Alzheimer’s show promise in mice
Provider: Molecular Psychiatry
Type: Link
Title: Discovery of a novel pseudo β-hairpin structure of N-truncated amyloid-β for use as a vaccine against Alzheimer’s disease - Molecular Psychiatry
Description: Molecular Psychiatry - Discovery of a novel pseudo β-hairpin structure of N-truncated...
Potential vaccine against Alzheimer’s show promise in mice
Provider: Universitätsmedizin Göttingen
Type: Link
Title: Home
Potential vaccine against Alzheimer’s show promise in mice
Provider: Alzheimer's Research UK
Type: Link
Title: What is Alzheimer's disease? - Alzheimer's Research UK
Description: Alzheimer's disease is the most common type of dementia, find out about the causes, symptoms, diagnosis and treatments here
Potential vaccine against Alzheimer’s show promise in mice
Provider: Alzheimersresearchuk
Type: JPG
Potential vaccine against Alzheimer’s show promise in mice
Provider: Alzheimer's Research UK
Type: Link
Title: When could aducanumab reach the UK? - Alzheimer's Research UK
Description: Today is a historic day for dementia research with the US Food and Drug Administration (FDA) announcing the first (conditional) licence of a new drug for Alzheimer’s disease in a generation.
Potential vaccine against Alzheimer’s show promise in mice
Provider: Molecular Psychiatry
Type: Link
Title: Discovery of a novel pseudo β-hairpin structure of N-truncated amyloid-β for use as a vaccine against Alzheimer’s disease - Molecular Psychiatry
Description: Molecular Psychiatry - Discovery of a novel pseudo β-hairpin structure of N-truncated...
Potential vaccine against Alzheimer’s show promise in mice
Provider: Twitter
Type: Twitter
Potential vaccine against Alzheimer’s show promise in mice
Provider: Alzheimer's Research UK
Type: Link
Title: Potential vaccine against Alzheimer’s show promise in mice -
Description: Scientists have developed a new vaccine shown to reduce Alzheimer’s symptoms in mice with features of the disease.
Potential vaccine against Alzheimer’s show promise in mice
Provider: Alzheimer's Research UK
Type: Link
Title: Alzheimer's Research UK - the UK's leading Alzheimer's research charity
Description: Alzheimer's Research UK are the UK's leading Alzheimer's research charity aiming to find a cure for dementia. Together we have the power to make breakthroughs possible.
Potential vaccine against Alzheimer’s show promise in mice
Provider: View Original
Type: Link
Title: Potential vaccine against Alzheimer’s show promise in mice -
Description: Scientists have developed a new vaccine shown to reduce Alzheimer’s symptoms in mice with features of the disease.
£50m boost for motor neurone disease research as part of wider government investment
£50m boost for motor neurone disease research as part of wider government investment
Provider: GOV.UK
Type: Link
Title: Government to invest £375 million in neurodegenerative disease research
Description: A £375 million investment to improve understanding and treatment for a range of neurodegenerative diseases.
£50m boost for motor neurone disease research as part of wider government investment
Provider: Alzheimersresearchuk
Type: JPG
£50m boost for motor neurone disease research as part of wider government investment
Provider: Twitter
Type: Twitter
£50m boost for motor neurone disease research as part of wider government investment
Provider: Alzheimer's Research UK
Type: Link
Title: £50m boost for motor neurone disease research as part of wider government investment - Alzheimer's Research UK
Description: The UK government has announced at least £50 million in funding for motor neurone disease (MND) research as part of a £375m investment into neurodegenerative disease research.
£50m boost for motor neurone disease research as part of wider government investment
Provider: Alzheimer's Research UK
Type: Link
Title: Alzheimer's Research UK - the UK's leading Alzheimer's research charity
Description: Alzheimer's Research UK are the UK's leading Alzheimer's research charity aiming to find a cure for dementia. Together we have the power to make breakthroughs possible.
£50m boost for motor neurone disease research as part of wider government investment
Provider: View Original
Type: Link
Title: £50m boost for motor neurone disease research as part of wider government investment - Alzheimer's Research UK
Description: The UK government has announced at least £50 million in funding for motor neurone disease (MND) research as part of a £375m investment into neurodegenerative disease research.